project report Promise2007

Das Projekt Promise2007 befasste sich mit der Erstellung und Auswertung einer Statistik zur Mitgliedersituation im Berufsverband Medizinischer Informatiker e.V.. Mit dem Ziel mehr über die Mitglieder und ihre derzeitige Situation zu erfahren wurde das Projekt an der Fachhochschule Hannover initiiert. Statistisch erfasst wurden Fragen zum Beschäftigungsverhältnis, zu Aus- und Weiterbildung, der beruflichen Situation und persönliche Angaben. Die Ergebnisse wurden ausgewertet und daraus wichtige Erkenntnisse für den BVMI e.V. abgeleitet, welche auf die weitere Verbandsarbeit Einfluss nehmen

Strong detection of the CMB lensingxgalaxy weak lensingcross-correlation from ACT-DR4,PlanckLegacy and KiDS-1000

We measure the cross-correlation between galaxy weak lensing data from the Kilo Degree Survey (KiDS-1000, DR4) and cosmic microwave background (CMB) lensing data from the Atacama Cosmology Telescope (ACT, DR4) and the Planck Legacy survey. We use two samples of source galaxies, selected with photometric redshifts, $(0.1<z_{\rm B}<1.2)$ and $(1.2<z_{\rm B}<2)$, which produce a combined detection significance of the CMB lensing/weak galaxy lensing cross-spectrum of $7.7\sigma$. With the lower redshift galaxy sample, for which the cross-correlation is detected at a significance of $5.3\sigma$, we present joint cosmological constraints on the matter density parameter, $\Omega_{\rm m}$, and the matter fluctuation amplitude parameter, $\sigma_8$, marginalising over three nuisance parameters that model our uncertainty in the redshift and shear calibration, and the intrinsic alignment of galaxies. We find our measurement to be consistent with the best-fitting flat $\Lambda$CDM cosmological models from both Planck and KiDS-1000. We demonstrate the capacity of CMB-weak lensing cross-correlations to set constraints on either the redshift or shear calibration, by analysing a previously unused high-redshift KiDS galaxy sample $(1.2<z_{\rm B}<2)$, with the cross-correlation detected at a significance of $7\sigma$. This analysis provides an independent assessment for the accuracy of redshift measurements in a regime that is challenging to calibrate directly owing to known incompleteness in spectroscopic surveys.Comment: 13 pages, 9 figures, 1 tables, submitted to A&

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Koncert Simfonijskog orkestra Muzičke akademije (Simfonijski orkestar i solisti Muzičke akademije Sveučilišta u Zagrebu, 25. 3. 2022.)

Koncert je održan na Muzičkoj akademiji u Koncertnoj dvorani "Blagoje Bersa" 25. 3. 2022. Izvođači: Simfonijski orkestar Muzičke akademije Sveučilišta u Zagrebu, solisti Nela Katalenić Klinar (sopran) i Nikola Smetko (saksofon). Dirigent: doc. art. Matija Fortuna. Program: 1. Mladen Tarbuk, Zlatko Tanodi, Dalibor Bukvić, Frano Đurović, Vjekoslav Nježić, Ante Knešaurek i Berislav Šipuš: Akademska suita (Fanfare – Allemande – Courante-Danse des esprits – Sarabande – Techno Air – Gigue – Post scriptum); 2. Camille Saint‐Saëns: L'attente (solistica: Nela Katalenić Klinar); 3. Boris Papandopulo: Koncert za saksofon i orkestar (solist: Nikola Smetko); 4. Johannes Brahms: 2. simfonija u D-duru, op. 73 (Allegro non troppo – Adagio non troppo – Allegretto grazioso (quasi andantino) – Allegro con spirito)

Koncert Simfonijskog orkestra Muzičke akademije (Simfonijski orkestar i solisti Muzičke akademije Sveučilišta u Zagrebu, 25. 3. 2022.)

Koncert je održan na Muzičkoj akademiji u Koncertnoj dvorani "Blagoje Bersa" 25. 3. 2022. Izvođači: Simfonijski orkestar Muzičke akademije Sveučilišta u Zagrebu, solisti Nela Katalenić Klinar (sopran) i Nikola Smetko (saksofon). Dirigent: doc. art. Matija Fortuna. Program: 1. Mladen Tarbuk, Zlatko Tanodi, Dalibor Bukvić, Frano Đurović, Vjekoslav Nježić, Ante Knešaurek i Berislav Šipuš: Akademska suita (Fanfare – Allemande – Courante-Danse des esprits – Sarabande – Techno Air – Gigue – Post scriptum); 2. Camille Saint‐Saëns: L'attente (solistica: Nela Katalenić Klinar); 3. Boris Papandopulo: Koncert za saksofon i orkestar (solist: Nikola Smetko); 4. Johannes Brahms: 2. simfonija u D-duru, op. 73 (Allegro non troppo – Adagio non troppo – Allegretto grazioso (quasi andantino) – Allegro con spirito)